it is necessary to take 2 times a day, three tablets after meals. I think we should strictly after meal. I once before a meal a couple of times and took very ill and then the stomach. Coinciding or additive effect because, for the third time did not want to re-examine, very much shoots in different locations and even stomach under the ribs. If after a heavy meal, it is normal. But on the effect somehow I can not say yet, is only half the jar was gone, and monthly painful enough, although it has begun recently, in the summer of 2013. The drink up until the end, I will add experience.